Coffee enemas use caffeine to help the body detox. The caffeine is preferentially absorbed into this system and is transported directly to the liver. t helps the liver to produce more bile* (which contains processed toxins) and moves bile out toward the small intestine for elimination. This seems to free up the liver to process more incoming toxic materials that have accumulated in the organs, tissues and bloodstream. The coffee does not go into the systemic circulation.
Caffeine also contains some alkaloids that stimulate the production of glutathione-S-transferase, an enzyme used by the liver to make the detox pathways run. It is pivotal in the formation of more glutathione, one of the main conjugation chemicals, enabling toxins to be eliminated via bile into the small intestine*. So, in other words, a coffee enema speeds up the detoxification process and minimises the backlog of yet-to-be-detoxified substances.